Exquisite insight into chromosome separation reveals the intricate relationships between molecular changes and large-scale ...
Reduction of chromosomal instability and inflammation is a common aspect of adaptation to aneuploidy
RPE-1 cells adapt to aneuploidy in vitro, a process characterized by reduced CIN and inflammation. This study shows that this ...
This is effected by the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase that is regulated by the Spindle Assembly Checkpoint (SAC). The SAC prevents the APC/C from recognising Cyclin B1, ...
Changing nutrient environments challenge cells as they affect both protein biosynthesis and cell cycle length. This work ...
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