The transgenic SAD mouse: a model of human sickle cell
WEBIn summary, the SAD mouse is a valuable model of the thrombotic and glomerulosclerotic complications of human sickle cell glomerulopathy and can serve for pathophysiologic studies, and, eventually, for prevention and therapy investigation.
Cardiorespiratory pathogenesis of sickle cell disease in a mouse …
WEBAug 17, 2017 · All adult SAD mice demonstrated impairments in exercise capacity and response to hypoxia, with a more severe phenotype in the tachypneic mice. The model revealed distinguishable subgroups of...
Genetic correction of sickle cell disease: Insights using ... - Nature
WEBWe assessed in vivo the potential curative threshold of fetal hemoglobin in the SAD transgenic mouse model of sickle cell disease using mating with mice expressing the human fetal Aγ-globin gene.
Sickle cell disease of transgenic SAD mice | Blood | American …
WEBNov 1, 1994 · The present study examines the cellular defects in vivo and pathologic changes observed in SAD-1 mice at atmospheric oxygenation as well as the effect of acute hypoxia. The transgenic mice showed generalized congestion and microvascular occlusions, occasionally with thrombosis and infarctions of …
SAD Mouse - an overview | ScienceDirect Topics
WEBSAD Mouse. Spleen histology in SCD mice is distorted showing massive expansion of red pulp, pooling of RBCs in sinusoids, vaso-occlusion, loss of lymphoid follicular structure, splenic infarcts, and progressive iron deposition as animals age [11,12,22,28,33,34]. From: Blood Cells, Molecules, and Diseases, 2024. Related terms: Globin; Heme; Platelet
SAD Mouse - an overview | ScienceDirect Topics
WEBThe use of mouse models to study human diseases is based on the genetic and phenotypic similarities between mouse and humans (face validity). The Berkeley and Townes SCD mice express only human globin chains and no mouse hemoglobin.
WEBTransgenic SAD mice showed in vitro and in vivo sickling of the erythrocytes with ultrastructural evidence of hemoglobin polymer- ization, microvascular occlusions and thrombosis and systemic
The transgenic SAD mouse: A model of human sickle cell glomerulopathy
WEBNov 1, 1994 · In summary, the SAD mouse is a valuable model of the thrombotic and glomerulosclerotic complications of human sickle cell glomerulopathy and can serve for pathophysiologic studies, and, eventually, for prevention and therapy investigation.
Sickle cell disease of transgenic SAD mice - PubMed
WEBNov 1, 1994 · SAD mice developed lethal vasoocclusive processes when exposed to reduced pO2 conditions, whereas control mice survived normally. The sensitivity to hypoxia appears to depend on the cellular level of HbSAD, because death occurred at pO2 of 42 mmHg for SAD mice and 49 mmHg for beta-thal/SAD.
Inhaled nitric oxide protects transgenic SAD mice from sickle …
WEBAug 1, 2003 · We developed a mouse model of hypoxia/reoxygenation lung injury closely mimicking the lung pathology of patients with sickle cell disease. This model involves the exposure of transgenic sickle cell (SAD) mice to hypoxia (8% oxygen) for 4, 10, and 46 hours followed by 2 hours of reoxygenation.