The Mesangial cell — the glomerular stromal cell | Nature …
WEBSep 10, 2021 · A growing body of evidence demonstrates that mesenchymal stromal cells, such as stromal fibroblasts, pericytes and vascular smooth muscle cells, not only specify the architecture of tissues but...
Mesangial pathology in glomerular disease: targets for …
WEBNov 11, 2010 · The mesangial, endothelial and epithelial cells of the glomerulus are involved in most pathologic processes. Animal models provide an understanding of the molecular basis of glomerular disease. These studies show that mesangial cells are critical players in initiation and progression of disease.
Mesangial Cells: The Tuft Guys of Glomerular Development
WEBAug 12, 2019 · The paramount importance of mesangial cells for the formation of the glomerular capillary tuft has been established through mouse genetic models lacking mesangial progenitor cell ingress or mesangial proliferation.
The role of the mesangium in glomerular function
WEBSep 1, 2023 · 3 MESANGIAL CELL PROLIFERATION AND HYPERTROPHY. Mesangial proliferation and hypertrophy are two findings in glomerular disease affecting the MCs, usually in combination with an expanded mesangial matrix.
WEBA growing body of evidence demonstrates that mesenchymal stromal cells, such as stromal fibroblasts, pericytes and vascular smooth muscle cells, not only specify the architecture of tissues but...
Mesangial cells regulate the single nephron GFR and preserve the ...
WEBDec 2, 2020 · The intraglomerular mesangial cells are located between the glomerular capillaries. Here we hypothesized that mesangial cells regulate the single nephron glomerular filtration rate (snGFR) and that mesangial cells support the integrity of the glomerular filtration barrier.
The regulation of mesangial cell proliferation - PubMed
WEBThis article reviews a number of factors that have been shown to play a role in controlling MC proliferation, including signaling molecules (e.g. Platelet-derived growth factor, Ras and Ca(2+)), cell cycle proteins (e.g. cyclin D1) and transcription factors (E2F).
WEB• Mesangial cell proliferation constitutes a frequent finding in a number of glomerular diseases that progress to glomerular sclerosis. The factors responsible for mesangial cell growth regulation in vivo are ill defined. However, cell culture data indicate that an array of mediators may have mitogenic or antimitogenic effects on these cells.
WEBA prominent histopathological feature of many human and experimental glomerular inflammatory diseases is cellu-lar hyperplasia in the mesangium, which is caused by proliferation of mesangial cells (MCs) and an influx of leukocytes (Fig. 1).
Mesangial cells and glomerular inflammation: from the
WEBThe increase in mesangial cell number is also due to proliferation of intrinsic mesangial cell population. Regulatory mechanisms of mesangial cell replication include a complex array of factors which control cell proliferation, survival and apoptosis.
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