Amphiregulin contributes to airway remodeling in chronic …
WEBAmphiregulin (Areg) is an epidermal growth factor receptor (EGFR) ligand suggested to regulate airway injury and repair. We sought to determine whether Areg expression increases in CLAD, localize the cellular source of Areg induction in CLAD, and assess its effects on airway matrix deposition.
Sustained amphiregulin expression in intermediate alveolar stem …
WEBSep 5, 2024 · Tang and colleagues elucidated the profibrotic role of sustained amphiregulin (AREG) derived from intermediate lung stem cells in driving pulmonary fibrosis and established AREG as a potential disease-severity indicator for idiopathic pulmonary fibrosis.
Regulation of the alveolar regenerative niche by amphiregulin …
WEBMar 6, 2023 · Lung regulatory T (Treg) cells are critical for maintaining blood oxygenation following influenza virus infection through production of the EGFR ligand amphiregulin (Areg); however, how Treg cells engage with progenitors within the …
Amphiregulin in lung diseases: A review - PMC - National Center …
WEBFeb 2, 2024 · Studies have shown that macrophages produce a high level of AREG in lipopolysaccharide-induced acute lung injury, activate the EGFR-AKT pathway, inhibit inflammatory cell infiltration and inflammatory factor expression, and have a …
Amphiregulin modulates murine lung recovery and fibroblast …
WEBAmphiregulin (AREG) can promote the lung repair process but can also lead to fibrotic remodeling. The objective of this study was to determine the role of AREG in altering recovery from environmental dust exposure in a murine in vivo model and in vitro using cultured human and murine lung fibroblasts.
EGFR Signaling in Lung Fibrosis - PMC - National Center for ...
WEBMar 14, 2022 · Consistent with these in vitro findings, AREG expression was markedly increased in the lungs of dox-CC10-TGF-β1 overexpressing mice and administration of AREG siRNA or AG1478 reduced collagen content and …
Amphiregulin induces CCN2 and fibronectin expression by TGF-β …
WEBDec 28, 2022 · Transforming growth factor (TGF)-β induces the release of AREG, which in turn activates EGFR, resulting in the activation of JNK and activator protein (AP)-1. Moreover, AP-1 mediates CCN2 and FN expression through AREG stimulation in A549 human lung epithelial cells, which leads to EMT.
Amphiregulin inhibits TNF-α-induced alveolar epithelial cell death ...
WEBAreg and TNF-α were synchronously produced by ALI lung tissues and M1 AMs, and Areg directly inhibited the TNF-induced apoptosis and transduction of caspase death signals in AECs via the EGFR pathway.
Chronic lung diseases are associated with gene expression …
WEBJul 14, 2021 · Amphiregulin (AREG), a ligand for epidermal growth factor receptor, is known to have essential roles in wound repair and inflammation resolution; furthermore, upregulation of AREG is associated...
Regulation of the alveolar regenerative niche by amphiregulin …
WEBDec 19, 2022 · Lung regulatory T (Treg) cells are critical for maintaining blood oxygenation following influenza virus infection through production of the EGFR ligand amphiregulin (Areg); however, how Treg cells engage with progenitors within the …
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